BroMosporine
BroMosporine Basic information
- Product Name:
- BroMosporine
- Synonyms:
-
- BroMosporine
- ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate
- N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
- CS-921
- Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester
- BroMosporine USP/EP/BP
- 11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase
- KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4
- CAS:
- 1619994-69-2
- MF:
- C17H20N6O4S
- MW:
- 404.44
- Product Categories:
-
- Inhibitors
- API
- Mol File:
- 1619994-69-2.mol
BroMosporine Chemical Properties
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml)
- pka
- 6.21±0.46(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
BroMosporine Usage And Synthesis
Description
Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1?Bromosporine was able to reactivate HIV-1 replication in different latency models.2
Uses
Bromosporine is a broad spectrum inhibitor for bromodomains.
in vivo
Bromosporine (100 mg/kg; i.p.; daily for 10 days) shows better antitumor activity than individual when co-treated with 5-Fluorouracil.html" class="link-product" target="_blank">5-FU (HY-90006)[1].
| Animal Model: | Female BALB/c nude mice (5-6 weeks; injected with 1?×?106?cells/100?μL of HT116?cells)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; daily for 10 days |
| Result: | Exhibited better antitumor activity than individual Bromosporine or 5-FU (HY-90006) when co-treated with the two agent. |
target
bromodomain
IC 50
HIV-1
storage
Store at +4°C
References
[1] SARAH PICAUD. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia[J]. Science Advances, 2016, 2 10. DOI:10.1126/sciadv.1600760
[2] HANYU PAN. The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.[J]. Oncotarget, 2017: 94104-94116. DOI:10.18632/oncotarget.21585
BroMosporineSupplier
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 027-027-87342388 18086026008
- sales@kaymke.com
- Tel
- +1 (866) 930-6790
- info@adooq.com
- Tel
- Mobile:13665161512