ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Epigenetics > Epigenetic Reader Domain inhibitors > BroMosporine
BroMosporine
BroMosporine Basic information
- Product Name:
- BroMosporine
- Synonyms:
-
- BroMosporine
- ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate
- N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
- CS-921
- Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester
- BroMosporine USP/EP/BP
- 11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase
- KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4
- CAS:
- 1619994-69-2
- MF:
- C17H20N6O4S
- MW:
- 404.44
- Product Categories:
-
- Inhibitors
- API
- Mol File:
- 1619994-69-2.mol
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BroMosporine Chemical Properties
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml)
- pka
- 6.21±0.46(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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BroMosporine Usage And Synthesis
Description
Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1?Bromosporine was able to reactivate HIV-1 replication in different latency models.2
Uses
Bromosporine is a broad spectrum inhibitor for bromodomains.
target
bromodomain
storage
Store at +4°C
References
1) Picaud?et al.?(2016),?Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia; Sci. Adv.?2?e1600760 2) Pan?et al.?(2017),?The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells; Oncotarget?8?94104
BroMosporineSupplier
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