CW069 Chemical Properties

Boiling point:

666.0±55.0 °C(Predicted)

Density 

1.559±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH

form 

solid

pka

2.69±0.10(Predicted)

color 

White to off-white

CW069 Usage And Synthesis

Description

CW069 is an allosteric inhibitor of KIFC/HSET (IC₅₀ = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC₅₀s = 86 and 181 μM, respectively).

Uses

CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.

References

[1]. watts ca, richards fm, bender a, et al. design, synthesis, and biological evaluation of an allosteric inhibitor of hset that targets cancer cells with supernumerary centrosomes. chem biol, 2013, 20(11): 1399-1410.

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