(-)-Pinoresinol 4-O-glucoside CAS#: 41607-20-9

ChemicalBook > Product Catalog > Natural Products > Lignans > (-)-Pinoresinol 4-O-glucoside

(-)-Pinoresinol 4-O-glucoside

Basic information Safety Supplier Related

(-)-Pinoresinol 4-O-glucoside Basic information

Product Name:

(-)-Pinoresinol 4-O-glucoside

Synonyms:

Pinoresinol beta-D-glucopyranoside
(-)-pinoresinol glucoside
β-D-Glucopyranoside, (1R,3aS,4R,6aS)-2-methoxy-4-[tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]phenyl
(-)-Pinoresinol glucoside

CAS:

41607-20-9

MF:

C26H32O11

MW:

520.53

Mol File:

41607-20-9.mol

Less

(-)-Pinoresinol 4-O-glucoside Usage And Synthesis

Uses

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 μM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].

Definition

ChEBI: (-)-Pinoresinol glucoside is a glycoside and a lignan.

in vivo

(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice^[2].

Animal Model:	27-30 g, Male Swiss albino mice^[2]
Dosage:	50 mg/kg
Administration:	P.o.; twenty days
Result:	Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%.

References

[1] Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21(24):9579. DOI:10.3390/ijms21249579
[2] Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72(12):1830-1839. DOI:10.1111/jphp.13358

(-)-Pinoresinol 4-O-glucosideSupplier

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Email: y.liu@mail.biobiopha.com

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Email: sales@reading-chemicals.com

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Email: 3423497944@qq.com

ALB Technology Limited

Tel: 702-983-3769
Email: sales@albtechnology.com

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Email: aileen@chemfaces.com

Less