KHELLIN
KHELLIN Basic information
- Product Name:
- KHELLIN
- Synonyms:
-
- 4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE
- 4,9-DIMETHOXY-7-METHYLFURO[3,2-G](1)BENZOPYRAN-5-ONE
- 2-g)(1)benzopyran-5-one,4,9-dimethoxy-7-methyl-5h-furo(
- 4,9-dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-(f)indene
- ammispasmin
- ammivin
- ammivisnagen
- norkel
- CAS:
- 82-02-0
- MF:
- C14H12O5
- MW:
- 260.24
- EINECS:
- 201-392-8
- Product Categories:
-
- AMIVIN
- Herb extract
- Inhibitors
- Mol File:
- 82-02-0.mol
KHELLIN Chemical Properties
- Melting point:
- 150154°C
- Boiling point:
- 180200°C0.05mm Hg
- Density
- 1.1954 (rough estimate)
- refractive index
- 1.4560 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- crystalline
- color
- light yellow
- Water Solubility
- 247.2g/L(25 ºC)
- Merck
- 14,5309
- BRN
- 263185
- LogP
- 1.770 (est)
- EPA Substance Registry System
- Khellin (82-02-0)
Safety Information
- Hazard Codes
- T
- Risk Statements
- 25-38-36/37/38-23/24/25
- Safety Statements
- 36/37/39-45-26
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- LV1050000
- HS Code
- 2932.99.7000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch)
MSDS
- Language:English Provider:SigmaAldrich
KHELLIN Usage And Synthesis
Uses
vasodilator (coronary), photosensitizer
Uses
Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.
Definition
ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.
brand name
Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).
Synthesis Reference(s)
Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002
General Description
Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.
Purification Methods
Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]
KHELLINSupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 4006608290; 18621169109
- market03@meryer.com
- Tel
- 021-20908456
- sales@BioChemBest.com
- Tel
- 021-67121386
- Sales-CN@TCIchemicals.com
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
KHELLIN(82-02-0)Related Product Information
- Ampicillin
- KHELLINONE
- khelloside
- VISNAGIN,VISNAGIN(RG)
- KHELLIN
- CHEMBRDG-BB 5160161
- 4,9-Dimethoxy-7-(2-phenylethenyl)-5H-furo[3,2-g][1]<br>benzopyran-5-one
- azaspirium chloride
- Mecrifurone
- Timefurone
- Amikhelline
- KHELLIN(VISAMMIN)(PRIMARY STANDARD)
- 4,9-DIMETHOXY-7-(TRICHLOROMETHYL)-5H-FURO[3,2-G]CHROMEN-5-ONE
- 4,9-DIMETHOXY-7-PENTAFLUOROETHYL-5H-FURO-[3,2-G]-CHROMENE-5-ONE
- 7-DIFLUOROMETHYL-4,9-DIMETHOXY-5H-FURO-[3,2-G]-CHROMENE-5-ONE
- 4,9-DIMETHOXY-7-(TRIFLUOROMETHYL)-5H-FURO[3,2-G]CHROMEN-5-ONE
- 4,9-DIETHOXY-7-METHYL-FURO[3,2-G]CHROMEN-5-ONE
- 4,9-DIMETHOXY-7-(1,1,2,2-TETRAFLUOROETHYL)-5H-FURO-[3,2-G]-CHROMENE-5-ONE