(3S,5R)-Rosuvastatin Chemical Properties

Boiling point:

745.6±70.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

solubility 

soluble in Methanol, Water

pka

4.25±0.10(Predicted)

form 

Solid

color 

Off-White to Pale Yellow

Stability:

Hygroscopic

(3S,5R)-Rosuvastatin Usage And Synthesis

Description

Rosuvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.

Uses

(3S,5R,6E)-Rosuvastatin is an isomer of Rosuvastatin(R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor.

Biological Activity

(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

(3S,5R)-Rosuvastatin(1242184-42-4)Related Product Information

• Rosuvastatin EP Impurity E (Calcium Salt)
• Pitavastatin Impurity 8
• Rosuvastatin Impurity 14
• (3R,5R)-Rosuvastatin
• N-DESMETHYL ROSUVASTATIN-D3
• Rosuvastatin
• (3S,5R)-Rosuvastatin Methyl Ester
• Rosuvastatin IMpurity (5-Oxo Rosuvastatin tert-Butyl Ester)
• Rosuvastatin Anhydro Lactone
• Rosuvastatin IsoaMy Ester
• Rosuvastatin EP impurity A
• N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide
• Rosuvastatin methyl ester
• tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
• 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol
• 3-Oxo Rosuvastatin SodiuM Salt
• Rosuvastatin ethyl ester
• Rosuvastatin EP impurity H