UNC2881 Chemical Properties

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO

form 

solid

pka

12.70±0.46(Predicted)

color 

White to off-white

UNC2881 Usage And Synthesis

Description

UNC2881 is an inhibitor of Mer (IC₅₀ = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC₅₀s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC₅₀ = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.

Uses

UNC2881 is a specific Mer tyrosine kinase inhibitor. It inhibits collagen-stimulated platelet aggregation.

target

Mer tyrosine kinase

storage

Store at +4°C

References

[1]. zhang w, mciver al, stashko ma, et al. discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. j med chem, 2013, 56(23): 9693-9700.

UNC2881(1493764-08-1)Related Product Information

• UNC2541
• UNC 1999
• UNC0379
• UNC 1025
• UNC2250
• GSK2656157
• GSK 2334470
• 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
• Afatinib
• AZD-9291
• UNC 669
• UNC0321
• UNC-1215
• UNC-926 Hydochloride
• UNC3230
• UNC0646
• UNC2025
• UNC 1079