Bonducellpin D Chemical Properties

Melting point:

216-217℃

Boiling point:

518.5±50.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

pka

13.57±0.70(Predicted)

form 

Solid

color 

White to off-white

Bonducellpin D Usage And Synthesis

Uses

Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV Mpro and MERS-CoV Mpro, with an Ki of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro[1][2][3].

Definition

ChEBI: Bonducellpin D is a sesquiterpene lactone.

References

[1] Gurung AB, et, al. Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 M pro enzyme through in silico approach. Life Sci. 2020 Aug 15;255:117831. DOI:10.1016/j.lfs.2020.117831
[2] Zheng Y, et, al. Caesalminaxins A-L, cassane diterpenoids from the seeds of Caesalpinia minax. J Nat Prod. 2013 Dec 27; 76(12): 2210-8. DOI:10.1021/np400545v
[3] Jiang RW, et, al. Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax. Bioorg Med Chem. 2002 Jul;10(7):2161-70. DOI:10.1016/s0968-0896(02)00072-x

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