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LY2584702

Basic information Safety Supplier Related

LY2584702 Basic information

Product Name:
LY2584702
Synonyms:
  • LY2584702
  • LY-2584702 (free base)
  • LY2584702 TsOH
  • 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702
  • 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
  • 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo
  • LY2584702 BASE
  • LY-2584702 free base (LY2584702)
CAS:
1082949-67-4
MF:
C21H19F4N7
MW:
445.42
Product Categories:
  • Inhibitors
Mol File:
1082949-67-4.mol
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LY2584702 Chemical Properties

storage temp. 
RT (des.)
solubility 
Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
form 
solid
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
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Safety Information

HS Code 
2933998090
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LY2584702 Usage And Synthesis

Description

LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.

Uses

LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.

References

1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441

LY2584702Supplier

Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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CEG Chemical Science&Technology Co., Ltd.
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Suzhou yacoo science co.,Ltd
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0512-87182056 18013166090
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lingling.qi@yacoo.com.cn
AdooQ Bioscience CHINA
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025-58849295 18951903616;
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