LY2584702
LY2584702 Basic information
- Product Name:
- LY2584702
- Synonyms:
-
- LY2584702
- LY-2584702 (free base)
- LY2584702 TsOH
- 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702
- 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
- 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo
- LY2584702 BASE
- LY-2584702 free base (LY2584702)
- CAS:
- 1082949-67-4
- MF:
- C21H19F4N7
- MW:
- 445.42
- Product Categories:
-
- Inhibitors
- Mol File:
- 1082949-67-4.mol
LY2584702 Chemical Properties
- storage temp.
- RT (des.)
- solubility
- Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
- form
- solid
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
LY2584702 Usage And Synthesis
Description
LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.
Uses
LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.
References
1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441
LY2584702Supplier
- Tel
- sales@boylechem.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- Mobile:13665161512
- Tel
- 0512-87182056 18013166090
- lingling.qi@yacoo.com.cn
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
LY2584702(1082949-67-4)Related Product Information
- LY2828360
- LY-2562175
- LY2228820
- Etalocib
- 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol
- LY3214996
- LY 2784544
- LY2409881 trihydrochloride
- LY-364947
- LY 88074
- (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
- Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2
- LY 294002 HYDROCHLORIDE
- Everolimus
- Y27632 (hydrochloride)
- Verteporfin
- SB 431542
- ABT 737