4-Bromo-2-nitrophenol Chemical Properties

Melting point:

90-94 °C (lit.)

Boiling point:

259.4±20.0 °C(Predicted)

Density 

1.8994 (rough estimate)

refractive index 

1.6090 (estimate)

storage temp. 

Sealed in dry,Room Temperature

pka

6.28±0.14(Predicted)

form 

Crystalline Powder or Crystals

color 

Yellow

Water Solubility 

Slightly soluble

InChI

InChI=1S/C6H4BrNO3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H

InChIKey

CUTFAPGINUFNQM-UHFFFAOYSA-N

SMILES

C1(O)=CC=C(Br)C=C1[N+]([O-])=O

CAS DataBase Reference

7693-52-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-20/22

Safety Statements 

26-36-36/37/39

WGK Germany 

3

RTECS 

SJ8370000

Hazard Note 

Harmful

HS Code 

29089990

MSDS

• Language:English Provider:2-Nitro-4-bromophenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4-Bromo-2-nitrophenol Usage And Synthesis

Description

4-bromo-2-nitrophenol is an essential intermediate for fine chemical engineering. It can be used to synthesize derivatives with biological activity, such as heterocyclic compounds as peptidase inhibitors for treating diabetes, introducing fluorine-containing groups as pesticides, and aminic compounds as Btk inhibitors for treating immune diseases.

Chemical Properties

yellow crystalline powder or crystals

Synthesis Reference(s)

The Journal of Organic Chemistry, 32, p. 300, 1967 DOI: 10.1021/jo01288a012
Synthesis, p. 287, 1989

General Description

The Suzuki coupling of 4-bromo-2-nitrophenol with boronic acid was studied.

Synthesis

The synthesis method of 4-bromo-2-nitrophenol comprises the following steps: preparing nitric acid with a concentration of 7-8 M; dissolving p-bromophenol in dichloroethane to obtain a substrate with a concentration of 1.8-2.2 M; injecting the nitric acid and the substrate into a continuous flow reactor through two pumps respectively, mixing, controlling the temperature at 55-75°C, the reaction pressure at 0.35-0.45 MPa, and reacting for 20-30 min.

4-Bromo-2-nitrophenol(7693-52-9)Related Product Information

• 2-Nitrophenol
• 4-Nitrophenol
• 4-Bromophenol
• 3-Bromoanisole
• Nitrophenol
• PICRIC ACID
• Bromine
• 3-Nitrophenol
• NITROGEN DIOXIDE
• 4-Bromo-2-fluoro-6-nitrophenol
• 5-BroMo-3-nitrosalicylaldehyde
• 4-BROMO-2-FLUORO-6-NITROANISOLE
• 4-BROMO-2-NITROANISOLE
• 3-BROMO-2-NITROPHENOL
• 5-Bromo-2-nitrophenol,3-Bromo-6-nitrophenol
• 2-BROMO-6-NITROPHENOL
• 4-Bromo-3-nitrophenol
• 2,5-DINITROPHENOL