ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > PI3K / Akt / mTOR > S6 Kinase Inhibitors > LY-2584702 (tosylate salt)
LY-2584702 (tosylate salt)
LY-2584702 (tosylate salt) Basic information
- Product Name:
- LY-2584702 (tosylate salt)
- Synonyms:
-
- 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine 4-methylbenzenesulfonate (1:1)
- LY-2584702 (tosylate salt)
- LY2584702 Tosylate
- 4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine p-toluenesulfonate
- LY-2584702;LY 2584702;LYS6K2
- LYS6K2
- LYS6K2(LY2584702) tosylate salt
- CS-2145
- CAS:
- 1082949-68-5
- MF:
- C28H27F4N7O3S
- MW:
- 617.62
- Product Categories:
-
- Inhibitors
- Mol File:
- 1082949-68-5.mol
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LY-2584702 (tosylate salt) Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:12.55(Max Conc. mg/mL);20.31(Max Conc. mM)
- form
- A crystalline solid
- color
- Light yellow to yellow
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LY-2584702 (tosylate salt) Usage And Synthesis
Uses
LY-2584702 is a p70 S6 kinase inhibitor with anti-tumor activity.
Biological Activity
LY2584702 is an orally active, ATP-competitive, potent and selective ribosomal protein S6 kinase (p70 S6 kinase, p70S6K, S6K1) inhibitor (IC50 = 4 nM; selective over 83 other kinases and 45 cell surface markers). LY2584702 inhibits HCT116 cellular S6 phosphorylation (IC50 0.1-0.24 μM) and shows anti-tumor efficacy in U87MG glioblastoma and HCT116 colon carcinoma xenograft models in vivo (2.5 mg/kg bid. po.).
LY-2584702 (tosylate salt)Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
Suzhou yacoo science co.,Ltd
- Tel
- 0512-87182056 18013166090
- lingling.qi@yacoo.com.cn