NBQX DISODIUM SALT Chemical Properties

Melting point:

361°C

Density 

1.6027 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Inert atmosphere,2-8°C

solubility 

methanol: 0.25 mg/mL

form 

solid

pka

7.55±0.20(Predicted)

color 

yellow

Stability:

Freezer at -20°C

InChIKey

UQNAFPHGVPVTAL-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

NBQX DISODIUM SALT Usage And Synthesis

Chemical Properties

Yellow Crystalline Solid

Uses

A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.

Uses

NBQX disodium salt hydrate has been used:

• in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
• as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
• in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSC_NMDAR)

Definition

ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.

General Description

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ .

Biochem/physiol Actions

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.

storage

Room temperature

NBQX DISODIUM SALT(118876-58-7)Related Product Information

• DNQX
• CNQX
• (RS)-AMPA
• 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE
• 1,8-Dihydroxyanthraquinone
• NBQX DISODIUM SALT
• 6-NITROQUINOXALINE-2,3-DIONE
• 4-Nitro-1-naphthylamine
• 6-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINE
• 7-NITRO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE
• N'-METHYL-4-NITROPHENYLENEDIAMINE-(1,2)
• 1,2,3,4-Tetrahydro-quinoxalin-6-ylamine
• 2,3-Quinoxalinedione,6-amino-1,4-dihydro-(9CI)
• NBQX DISODIUM SALT
• N-ACETYL-4-NITRO-1-NAPHTHYLAMINE
• [10-3H]NBQX
• ACETAMIDE, N-(4-AMINO-1-NAPHTHYL)-
• 2,3-QUINOXALINEDIONE, 1,4-DIHYDRO-6-NITRO-, MONOHYDRATE