[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid Basic information
- Product Name:
- [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
- Synonyms:
-
- MPEG5-OCH2COOH
- [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
- 3,6,9,12,15,18-Hexaoxanonadecanoic acid
- m-PEG6-CH4COOH
- mPEG5-acetic acid
- mPEG5-CH2COOH
- 2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
- 3,6,9,12,15,18-Hexaoxa-nonadecansaeure
- CAS:
- 16142-03-3
- MF:
- C13H26O8
- MW:
- 310.34
- Mol File:
- 16142-03-3.mol
[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid Chemical Properties
- Boiling point:
- 418.6±40.0 °C(Predicted)
- Density
- 1.124±0.06 g/cm3(Predicted)
- pka
- 3.39±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid Usage And Synthesis
Description
m-PEG6-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological Activity
m-PEG5-CH2COOH is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Non-cleavable < span> | PEGs
|
[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acidSupplier
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[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid(16142-03-3)Related Product Information
- 3,6,9,12,15,18-Hexaoxanonadecane-1-thiol
- HEXAETHYLENE GLYCOL MONOMETHYL ETHER
- mPEG8-Alkyne
- MPEG3-CH2CH2COOH
- m-PEG5-bromide
- METHOXYPOLYETHYLENE GLYCOL 5,000 PROPIONIC ACID
- m-PEG13-acid
- MPEG3-Propyne
- MPEG6-CH2CH2COOH
- MPEG7-CH2CH2COOH
- MPEG4-CH2CH2COOH
- 1-{2-[2-(2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- Polyethylene Glycol
- mPEG3-CH2COOH
- mPEG6-CH2COOH
- 2,5,8,11,14-pentaoxahexadecan-16-oic acid
- Poly(propylene glycol)