3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOCYANATE Chemical Properties

Boiling point:

62 °C (2 mmHg)

Density 

1.476 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.43(lit.)

Flash point:

154 °F

form 

Liquid

color 

Clear colorless

Water Solubility 

Hydrolyzes with water.

Sensitive 

Moisture Sensitive

BRN 

542272

CAS DataBase Reference

16588-74-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

23-26-27-28-36/37/39

RIDADR 

UN 2206 6.1/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29291090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOCYANATE Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

3,5-Bis(trifluoromethyl)phenyl isocyanate is used in Chemical derivatization of amino-functionalized model surfaces. Preparation of arylaminothiocarbonylpyridinium zwitterionic salts, via an exothermic reaction with 4-pyrrolidinopyridine. Synthesis of (S)-3-hydroxymethyl-2-methoxymethoxy-2?-(3-(3,5-bis(trifluoromethyl)phenyl)uryl-benzyl)-1,10-binaphthalene. Synthesis of 1-[3,5-bis(trifluoromethyl) phenyl]-3-(2-pyridyl)thiourea, via reaction with 2-amino pyridine in MeCN.

Uses

3,5-Bis(trifluoromethyl)phenyl isocyanate may be used in following studies:

• Chemical derivatization of amino-functionalized model surfaces.
• Preparation of arylaminothiocarbonylpyridinium zwitterionic salts, via an exothermic reaction with 4-pyrrolidinopyridine.
• Synthesis of (S)-3-hydroxymethyl-2-methoxymethoxy-2′-(3-(3,5-bis(trifluoromethyl)phenyl)uryl-benzyl)-1,10-binaphthalene.
• Synthesis of 1-[3,5-bis(trifluoromethyl) phenyl]-3-(2-pyridyl)thiourea, via reaction with 2-amino pyridine in MeCN.

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOCYANATE(16588-74-2)Related Product Information

• 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE
• ISOCYANIC ACID
• m-Tolyl isocyanate
• 3,5-DIMETHYLPHENYL ISOCYANATE
• 3,5-Dimethylaniline
• 3-Methyl-5-trifluoromethylaniline
• 3-(Trifluoromethyl)phenyl isocyanate
• 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOCYANATE
• Phenyl isocyanate
• 1,3-Bis(trifluoromethyl)-benzene
• 3,5-Bis(trifluoromethyl)aniline