Pyrazofurin
Pyrazofurin Basic information
- Product Name:
- Pyrazofurin
- Synonyms:
-
- 3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide
- 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid
- 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide
- antibiotica23813
- beta-pyrazomycin
- compound47599
- nsc143095
- pirazofurin
- CAS:
- 30868-30-5
- MF:
- C9H13N3O6
- MW:
- 259.22
- Product Categories:
-
- Bases & Related Reagents
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Mol File:
- 30868-30-5.mol
Pyrazofurin Chemical Properties
- Boiling point:
- 584.4±50.0 °C(Predicted)
- Density
- 1.785±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO, Water (Slightly)
- pka
- 7.17±0.50(Predicted)
- form
- powder
- color
- white to light brown
- optical activity
- [α]/D -49 to -39°, c = 0.5 in H2O
- Stability:
- Hygroscopic
Pyrazofurin Usage And Synthesis
Uses
Geldanamycin (G304500) derivative.
Definition
ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.
Biochem/physiol Actions
Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.
Enzyme inhibitor
This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.
PyrazofurinSupplier
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Pyrazofurin(30868-30-5)Related Product Information
- Pyrazole-3-carboxamide
- 1-(5-methyl-1H-pyrazol-3-yl)methanamine
- 5'-deoxypyrazofurin
- 4-hydroxypyrazole
- 5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE
- 5-methyl-1H-pyrazole-3-carbaldehyde
- 3-(Aminomethyl)pyrazole
- 3-ETHYL-1H-PYRAZOLE-5-CARBALDEHYDE
- (1H-PYRAZOL-3-YL)METHANOL
- 4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE
- 2H-PYRAZOLE-3-CARBALDEHYDE
- Pyrazofurin
- 3,5-Dimethylpyrazole
- 2,2'-Oxydipropanol