Basic information Safety Supplier Related

Pyrazofurin

Basic information Safety Supplier Related

Pyrazofurin Basic information

Product Name:
Pyrazofurin
Synonyms:
  • 3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide
  • 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid
  • 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide
  • antibiotica23813
  • beta-pyrazomycin
  • compound47599
  • nsc143095
  • pirazofurin
CAS:
30868-30-5
MF:
C9H13N3O6
MW:
259.22
Product Categories:
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
Mol File:
30868-30-5.mol
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Pyrazofurin Chemical Properties

Boiling point:
584.4±50.0 °C(Predicted)
Density 
1.785±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO, Water (Slightly)
pka
7.17±0.50(Predicted)
form 
powder
color 
white to light brown
optical activity
[α]/D -49 to -39°, c = 0.5 in H2O
Stability:
Hygroscopic
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Pyrazofurin Usage And Synthesis

Uses

Geldanamycin (G304500) derivative.

Definition

ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.

Biochem/physiol Actions

Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.

Enzyme inhibitor

This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.

PyrazofurinSupplier

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