Idarubicin
Idarubicin Basic information
- Product Name:
- Idarubicin
- Synonyms:
-
- 11-trihydroxy-(7s-cis)-alpha-l-lyxo-hexopyranosyl)oxy)-
- 4-demethoxy-daunomyci
- 4-demethoxydaunomycin
- 4-demethoxydaunorubicin
- 4-Demethoxy-daunorubicin
- 7,8,9,10-tetrahydro-9-acetyl-7-((3-amino-2,3,6-trideoxy-12-naphthacenedione
- nsc-256439
- (7S)-9-Acetyl-7β-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9β,11-trihydroxy-5,12-naphthacenedione
- CAS:
- 58957-92-9
- MF:
- C26H27NO9
- MW:
- 497.49
- EINECS:
- 1806241-263-5
- Product Categories:
-
- Active Pharmaceutical Ingredients
- Mol File:
- 58957-92-9.mol
Idarubicin Chemical Properties
- Boiling point:
- 589.46°C (rough estimate)
- Density
- 1.3477 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- form
- solid
- pka
- pKa 4.73± 0.21 (Uncertain)
Safety Information
- Hazard Codes
- T+
- Risk Statements
- 60-61-28-40
- Safety Statements
- 53-45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- HB7877000
MSDS
- Language:English Provider:SigmaAldrich
Idarubicin Usage And Synthesis
Chemical Properties
Idarubicin Hydrochloride: C????H????NO??HCl. [57852-57-0]. Bright orange crystalline powder, melting point 183–185°C; melting point 172–174°C has also been reported. [α]D20+205° (C=0.1, methanol); also reported as [α]D20+188° (C=0.10, methanol).
Uses
Antineoplastic.
Indications
Idarubicin (Idamycin) differs from its parent compound, daunorubicin, by the absence of the methoxy group in the anthracycline ring structure. Its mechanisms of action and resistance are similar to those of doxorubicin and daunorubicin; however, it is more lipophilic and more potent than these other anthracyclines. Idarubicin undergoes extensive hepatic metabolism and biliary excretion. Adverse reactions of idarubicin are similar to those of its congeners.
Definition
ChEBI: Idarubicin is a monosaccharide derivative, an anthracycline antibiotic and a deoxy hexoside. It derives from a hydride of a tetracene.
brand name
Zavedos ; Idamycin/Idamycin PFS
Mechanism of action
Idarubicin is an anthracycline antitumor drug. It mainly exerts its therapeutic effect on acute leukemia by binding to DNA and inhibiting the activity of topoisomerase II, thereby disrupting DNA replication and transcription and causing DNA damage and cell death.
Clinical Use
Idarubicin is a chemotherapy drug used to treat acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL).
IC 50
Topoisomerase II
Idarubicin Preparation Products And Raw materials
Raw materials
IdarubicinSupplier
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- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
- Tel
- 27-027-83314682 13554138826
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- 010-56205725
- waley188@sohu.com
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Idarubicin(58957-92-9)Related Product Information
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