2-Chloro-6-methylpyrazine Chemical Properties

Melting point:

49-52

Boiling point:

83°C/35mmHg(lit.)

Density 

1.234±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

-0.89±0.10(Predicted)

color 

White to Almost white

InChIKey

CKUVSPQGYLELRG-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

22-26-36/37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29339900

2-Chloro-6-methylpyrazine Usage And Synthesis

Chemical Properties

Solid

Uses

2-Chloro-6-methylpyrazine was used in the synthesis of palm site inhibitors of HCV NS5B polymerase and potent dipeptidyl peptidase IV inhibitors.

Synthesis

Step 3: To a 5L sealed reaction tube was added (6-chloropyrazin-2-yl)acetic acid (220 g, 1.27 mol, 1.00 equiv) and deionized water (3L). The reaction mixture was stirred at 130 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted with ether (2 x 3 L). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 238 g (73% yield) of 2-chloro-6-methylpyrazine as a yellow solid.

References

[1] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0325; 0322

2-Chloro-6-methylpyrazine(38557-71-0)Related Product Information

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• Hydrochlorothiazide
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• Chloroacetic acid
• 2-amino-3-chloro-5-methyl-pyrazine
• 2-CHLORO-3-METHYLPYRAZINE
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