Basic information Safety Supplier Related

METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE

Basic information Safety Supplier Related

METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE Basic information

Product Name:
METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE
Synonyms:
  • 3-HYDROXYISOXAZOLE-5-CARBOXYLIC ACID*MET HYL ESTER
  • METHYL 3-OXOOXAZOLE-5-CARBOXYLATE
  • METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE
  • METHYL 3-HYDROXYISOXAZOLE-5-CARBOXYLATE
  • METHYL 3-HYDROXYL-5-ISOXAZOLECARBOXYLATE
  • Methyl 3-hydroxyisoxazole-5-carboxylate,99%
  • Methyl 3-hydroxy-1,2-oxazole-5-carboxylate
  • 2,3-DIHYDRO-3-OXO-5-ISOXAZOLECARBOXYLIC ACID, METHYL ESTER
CAS:
10068-07-2
MF:
C5H5NO4
MW:
143.1
Product Categories:
  • Heterocyclic Compounds
  • Aromatics Compounds
  • Aromatics
  • Intermediates
  • Building Blocks
  • Heterocyclic Building Blocks
  • pharmacetical
  • Heterocycles series
  • Isoxazoles
Mol File:
10068-07-2.mol
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METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE Chemical Properties

Melting point:
160-163 °C(lit.)
Boiling point:
261.15°C (rough estimate)
Density 
1.5918 (rough estimate)
refractive index 
1.5820 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform, Ethanol, Ether, Ethyl Acetate, Methanol
form 
Powder
pka
11.25±0.40(Predicted)
color 
Light Yellow
InChIKey
BBFWUUBQSXVHHZ-UHFFFAOYSA-N
CAS DataBase Reference
10068-07-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29349990

MSDS

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METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE Usage And Synthesis

Chemical Properties

Light Yellow Powder

Uses

An interesting intermediate

Uses

Methyl 3-hydroxy-5-isoxazolecarboxylate was used in the enantioselective synthesis of a key precursor to the tetracycline antibiotics. It was also used in the preparation of formamidinopiperidine analog, an N-amidinopiperidine compound.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 20, p. 965, 1977 DOI: 10.1021/jm00217a023

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