4-Amino-2-bromopyridine Chemical Properties

Melting point:

92-96 °C

Boiling point:

321.3±22.0 °C(Predicted)

Density 

1.710±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

4.89±0.30(Predicted)

form 

Crystalline Powder or Powder

color 

White to pale brown to orange

Water Solubility 

Slightly soluble in water.

BRN 

108928

InChI

InChI=1S/C5H5BrN2/c6-5-3-4(7)1-2-8-5/h1-3H,(H2,7,8)

InChIKey

GNTGEMWEXKBWBX-UHFFFAOYSA-N

SMILES

C1(Br)=NC=CC(N)=C1

CAS DataBase Reference

7598-35-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-36/37/38-20/21/22

Safety Statements 

26-36/37/39-36/37/38-36-36/37

WGK Germany 

3

Hazard Note 

Harmful/Irritant

HazardClass 

IRRITANT

HS Code 

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Amino-2-bromopyridine Usage And Synthesis

Chemical Properties

Light yellow Cryst

Uses

4-Amino-2-bromopyridine is used as medical intermediate.

Synthesis

A conventional synthetic route toward 4-amino-2-bromopyridine starts from its precursor, 2-bromo-4-nitropyridine, where the nitro group is reduced to an amino group via the action of elemental metals. Common reduction systems include iron powder with acetic acid, magnesium powder with titanium tetrachloride, and so forth. Generally, the reduction system using iron powder and acetic acid requires high-temperature conditions for proceeding. After the reaction completes, pyridine tends to form a salt with protic acids, thus pH adjustment is necessary during the post-treatment process to liberate 4-Amino-2-bromopyridine from its salt form.

4-Amino-2-bromopyridine(7598-35-8)Related Product Information

• 4-Dimethylaminopyridine
• 1-Hexadecylpyridinium bromide
• Glycine
• 2-Bromopyridine
• ALTRENOGEST
• 2-Aminopyridine
• 3-Aminopyridine
• 3-Bromoanisole
• Betaine
• 4-Aminopyridine
• 2-Bromo-4-nitropyridine 1-oxide
• 2-Bromo-4-nitropyridine
• 4-Amino-3-bromopyridine
• 3-AMINO-2-BROMOPYRIDINE
• 4-(BOC-AMINO)-2-BROMOPYRIDINE
• Bromine
• 2-Amino-5-bromopyridine-3-methanol
• 2-bromo-4-hydrazinopyridine