2-(2-Propynyloxy)ethylamine CAS#: 122116-12-5

2-(2-Propynyloxy)ethylamine Basic information

Product Name:

2-(2-Propynyloxy)ethylamine

Synonyms:

2-(2-Propynyloxy)ethylamine
Propargyl-PEG1-amine
2-(2-Propyn-1-yloxy)ethanamine
2-prop-2-ynoxyethanamine
2-(2-Propynyloxy)ethylamine >
Propargyl-PEG1-NH2
Ethanamine, 2-(2-propyn-1-yloxy)-
Alkyne-PEG1-NH2

CAS:

122116-12-5

MF:

C5H9NO

MW:

99.13

EINECS:

808-208-0

Product Categories:

peg

Mol File:

122116-12-5.mol

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2-(2-Propynyloxy)ethylamine Chemical Properties

Boiling point:: 153.4±15.0 °C(Predicted)
Density: 0.945±0.06 g/cm3(Predicted)
refractive index: 1.4530 to 1.4570
storage temp.: 2-8°C, protect from light
form: clear liquid
pka: 8.42±0.10(Predicted)
color: Colorless to Light orange to Yellow

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Safety Information

RIDADR: UN 2734 8/3/PG II
HazardClass: 8/3
PackingGroup: II
HS Code: 2942000090

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2-(2-Propynyloxy)ethylamine Usage And Synthesis

Uses

Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG1-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

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