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Sodium sulfadiazine

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Sodium sulfadiazine Basic information

Product Name:
Sodium sulfadiazine
Synonyms:
  • 4-AMINO-N-[2-PYRIMIDINYL]BENZENESULFONAMIDE SODIUM SALT
  • (n(sup1)-2-pyrimidinylsulfanilamido)-sodiu
  • 2-sulfanilamidopyrimidinesodiumsalt
  • 4-amino-n-2-pyrimidinyl-benzenesulfonamidmonosodiumsalt
  • monosodium2-sulfanilamidopyrimidine
  • n(sup1)-2-pyrimidinylsulfanilamidemonosodiumsalt
  • n(sup1)-2-pyrimidinyl-sulfanilamidmonosodiumsalt
  • n(sup1)-2-pyrimidinyl-sulfanilamidn(sup1)-sodiumderiv
CAS:
547-32-0
MF:
C10H11N4NaO2S
MW:
274.27
EINECS:
208-919-0
Product Categories:
  • pharmaceutical
  • API
  • 547-32-0
Mol File:
547-32-0.mol
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Sodium sulfadiazine Chemical Properties

Melting point:
>300°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
BRN 
4068213
Stability:
Hygroscopic
InChI
InChI=1S/C10H10N4O2S.Na.H/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;;/h1-7H,11H2,(H,12,13,14);;
InChIKey
JLDCNMJPBBKAHH-UHFFFAOYSA-N
SMILES
S(C1C=CC(N)=CC=1)(=O)(=O)NC1=NC=CC=N1.[NaH]
CAS DataBase Reference
547-32-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-42/43
Safety Statements 
22-26-36/37-45
RIDADR 
3249
WGK Germany 
3
RTECS 
WP2000000
F 
10-21
HazardClass 
6.1(b)
PackingGroup 
III

MSDS

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Sodium sulfadiazine Usage And Synthesis

Chemical Properties

White to yellow crystalline powder

Uses

Sulfadiazine Sodium Salt can be used as reactant/reagent in preparation and crystal structure of aminophenyl sulfonamide tetrahalides, hydrochloride and hydrobromide cocrystals with iodine.

Uses

Sulfadiazine may be used as an internal standard for the determination of sulfapyridine in biological samples using high-performance liquid chromatography technique.

General Description

Soluble sulfadiazine is an anhydrous, white, colorless, crystallinepowder soluble in water (1:2) and slightly soluble inalcohol. Its water solutions are alkaline (pH 9–10) and absorbcarbon dioxide from the air, with precipitation of sulfadiazine.It is administered as a 5% solution in sterile waterintravenously for patients requiring an immediately highblood level of the sulfonamide.

in vivo

In this study, the effectiveness of Sulfadiazine sodium and Pyrimetamine for the treatment of mice during acute infection with different atypical T. gondii strains was evaluated. Swiss mice were infected with seven T. gondii strainsl. The infected mice were treated with 10-640?mg/kg per day of Sulfadiazine sodium, 3-200?mg/kg per day of Pyrimetamine, or a combination of both drugs with a lower dosage. A descriptive analysis was used to assess the association between susceptibility to sodium and/or Pyrimetamine and the genotype. The TgCTBr4 and TgCTBr17 strains (genotype 108) presented lower susceptibility to sodium or Pyrimetamine treatment. The TgCTBr1 and TgCTBr25 strains (genotype 206) presented similar susceptibility to PYR but not sodium treatment. The TgCTBr9 strain (genotype 11) was the only strain with high susceptibility to treatment with both drugs [1].

IC 50

Toxoplasma

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