Bis-propargyl-PEG6 Chemical Properties

Boiling point:

381.7±37.0 °C(Predicted)

Density 

1.053±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

form 

Oil

color 

Colorless to light yellow

Bis-propargyl-PEG6 Usage And Synthesis

Description

Bis-propargyl-PEG6 has two propargyl groups which can participate in Click Chemistry reactions to yield a stable triazole linkage with azide compounds; copper is needed as a catalyst. The 6 units of PEG increase the hydrophilicity of the compound.

Uses

Bis-propargyl-PEG5 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG5 is used for the synthesis of carbohydrate receptors (SCRs) with anti-Zika activity[1]. Bis-propargyl-PEG5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors. DOI: 10.1021/acs.jmedchem.9b00142. DOI:10.1021/acs.jmedchem.9b00142

Bis-propargyl-PEG6(185378-83-0)Related Product Information

• Propargyl-PEG5-t-butyl ester
• 2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL
• Propargyl-PEG3-t-butyl ester
• Propargyl-PEG4-NHS ester
• propargyl-PEG3-Acid
• Propargyl-PEG3-NHS ester
• Propargyl-PEG5-alcohol
• Bis-propargyl-PEG10
• Bis-propargyl-PEG8
• Bis-Propargyl-PEG7
• Bis-propargyl-PEG11
• DIPROPARGYL ETHER
• Bis-Propargyl-PEG10
• Bis-Propargyl-PEG9
• Bis-Propargyl-PEG4
• alpha, oMega-Dipropionic acid triethylene glycol
• Diethylene Glycol Bis(2-propynyl) Ether
• 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne