Propargyl-PEG3-t-butyl ester Chemical Properties

Boiling point:

337.2±27.0 °C(Predicted)

Density 

1.023±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, stored under nitrogen

form 

Liquid

color 

Colorless to light yellow

Propargyl-PEG3-t-butyl ester Usage And Synthesis

Description

Propargyl-PEG3-t-butyl ester consists of an alkyne group and a t-butyl ester group. The alkyne groupreacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The protected carboxyl group can be deprotected under acidic conditions.

Uses

Propargyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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