Basic information Safety Supplier Related

Hydroxy-PEG3-PFP ester

Basic information Safety Supplier Related

Hydroxy-PEG3-PFP ester Basic information

Product Name:
Hydroxy-PEG3-PFP ester
Synonyms:
  • Hydroxy-PEG3-PFP ester
  • Hydroxy-PEG3-C2-PFP ester
  • Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
CAS:
1807537-40-1
MF:
C15H17F5O6
MW:
388.28
Mol File:
1807537-40-1.mol
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Hydroxy-PEG3-PFP ester Chemical Properties

Boiling point:
440.3±45.0 °C(Predicted)
Density 
1.385±0.06 g/cm3(Predicted)
pka
14.36±0.10(Predicted)
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Hydroxy-PEG3-PFP ester Usage And Synthesis

Biological Activity

Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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