Basic information Safety Supplier Related

Propargyl-PEG4-Tos

Basic information Safety Supplier Related

Propargyl-PEG4-Tos Basic information

Product Name:
Propargyl-PEG4-Tos
Synonyms:
  • 3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate
  • Propargyl-PEG4-Tos
  • Propargyl-PEG5-Tos
  • 3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate)
  • 2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
CAS:
875770-32-4
MF:
C18H26O7S
MW:
386.46
Mol File:
875770-32-4.mol
More
Less

Propargyl-PEG4-Tos Chemical Properties

Boiling point:
498.1±45.0 °C(Predicted)
Density 
1.177±0.06 g/cm3(Predicted)
form 
Liquid
color 
Colorless to light yellow
More
Less

Propargyl-PEG4-Tos Usage And Synthesis

Description

Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Biological Activity

Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Propargyl-PEG4-TosSupplier

Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Email
han_yajun@dctc.daicel.com
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Email
product02@bidepharm.com
Borenpharm Co., Ltd
Tel
027-65563561
Email
sales@borenpharm.com
Jinan elephant international trading co., LTD
Tel
Email
13006575422@163.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com

PEGs

Cleavable