Propargyl-PEG4-Tos
Propargyl-PEG4-Tos Basic information
- Product Name:
- Propargyl-PEG4-Tos
- Synonyms:
-
- 3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate
- Propargyl-PEG4-Tos
- Propargyl-PEG5-Tos
- 3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate)
- CAS:
- 875770-32-4
- MF:
- C18H26O7S
- MW:
- 386.46
- Mol File:
- 875770-32-4.mol
Propargyl-PEG4-Tos Chemical Properties
- Boiling point:
- 498.1±45.0 °C(Predicted)
- Density
- 1.177±0.06 g/cm3(Predicted)
Propargyl-PEG4-Tos Usage And Synthesis
Description
Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Biological Activity
Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Cleavable
|