Tos-PEG3-CH2CO2tBu
Tos-PEG3-CH2CO2tBu Basic information
- Product Name:
- Tos-PEG3-CH2CO2tBu
- Synonyms:
-
- Tos-PEG3-CH2CO2tBu
- Tos-PEG2-CH2COOtBu
- tert-butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate
- 2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-Acetic acid, 1,1-dimethylethyl
- Tos-PEG2-CH2-Boc
- Acetic acid, 2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
- {2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-acetic acid tert-butyl ester
- Tos-PEG2-CH2COOtBu/Acetic acid, 2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
- CAS:
- 882518-89-0
- MF:
- C17H26O7S
- MW:
- 374.45
- Mol File:
- 882518-89-0.mol
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Tos-PEG3-CH2CO2tBu Chemical Properties
- storage temp.
- Store at Room Tem.
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
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Tos-PEG3-CH2CO2tBu Usage And Synthesis
Description
Tos-PEG3-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tos-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6
Tos-PEG3-CH2CO2tBuSupplier
Jinan elephant international trading co., LTD
- Tel
- 13006575422@163.com
Shanghai Yihe Biological Technology Co., Ltd.
- Tel
- 021-68882955 17721395025
- 2423903095@qq.com
Amatek Scientific Co. Ltd.
- Tel
- 0512-56316828
- info@amateksci.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Nextpeptide Inc
- Tel
- +86-0571-81612335 +8613336028439
- sales@nextpeptide.com
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Tos-PEG3-CH2CO2tBu(882518-89-0)Related Product Information
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- (2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid tert-butyl ester