tetrahydrofuran-2-carboximidamide hydrochloride Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

tetrahydrofuran-2-carboximidamide hydrochloride Usage And Synthesis

Synthesis

The general procedure for the synthesis of tetrahydrofuran-2-carboxamidine hydrochloride from methyl tetrahydrofuran-2-carboxylate was as follows: 41.1 g (768 mmol, 5 eq.) of ammonium chloride was suspended in 400 ml of anhydrous toluene under argon protection and the mixture was cooled to 0 °C. 385 ml (768 mmol, 5 eq.) of a hexane solution of 2M trimethylaluminum was slowly added dropwise, followed by stirring the reaction mixture at room temperature until no gas was released. After addition of 20 g (154 mmol, 1 eq.) of methyl tetrahydrofuran-2-carboxylate, the mixture was stirred in an oil bath at 80 °C overnight. Upon completion of the reaction, the mixture was cooled to 0 °C and 200 ml of methanol was slowly added while stirring was continued for 1 h at room temperature. After filtration, the solid was washed several times with methanol, the filtrate was combined and concentrated to dryness in vacuum. Finally 15.9 g (69% yield) of the target product tetrahydrofuran-2-carboxamidine hydrochloride was obtained.

References

[1] Patent: WO2003/93270, 2003, A1. Location in patent: Page/Page column 22

tetrahydrofuran-2-carboximidamide hydrochloride(619329-27-0)Related Product Information

• TETRAHYDRO-PYRAN-3-CARBALDEHYDE
• TETRAHYDROPYRAN-2-METHANOL
• tetrahydro-2-furyl acetate
• TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER
• TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE
• 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL
• Sodium oxane-4-sulfinate
• Ethyl tetrahydro-2-furoate
• TETRAHYDROFURAN-3-CARBOXALDEHYDE 98
• ETHYL TETRAHYDROPYRAN-4-YL-ACETATE
• [(Tetrahydro-2H-pyran-4-yl)methyl]hydrazine dihydrochloride
• Tetrahydropyran-4-boronic acid pinacol ester
• 4-Aminotetrahydro-2H-pyran acetate