3-Quinolinecarboxylic acid Chemical Properties

Melting point:

277-280 °C (lit.)

Boiling point:

303.81°C (rough estimate)

Density 

1.2427 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

2.20±0.30(Predicted)

color 

White to slightly beige

BRN 

126542

InChI

InChI=1S/C10H7NO2/c12-10(13)8-5-7-3-1-2-4-9(7)11-6-8/h1-6H,(H,12,13)

InChIKey

DJXNJVFEFSWHLY-UHFFFAOYSA-N

SMILES

N1C2C(=CC=CC=2)C=C(C(O)=O)C=1

CAS DataBase Reference

6480-68-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36/38

Safety Statements 

22-24/25-37/39-26-37

WGK Germany 

3

HS Code 

29334900

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:3-Quinolinecarboxylic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Quinolinecarboxylic acid Usage And Synthesis

Chemical Properties

WHITE TO SLIGHTLY BEIGE POWDER

Uses

A quinoline derivative with antimicrobial activity.

General Description

The antibacterial activity of 3-quinolinecarboxylic acid derivatives were evaluated.

Synthesis

In a Schlenk (50 mL) reaction flask with a carbon dioxide balloon attached at the stub, Cu(OAc)2.H2O (0.0125 mmol), 1,2-bis(diphenylphosphino)benzene (0.018 mmol), and 1,4-dioxane (2.0 mL) were added with stirring, and then the flask was placed at 60 C oil bath for 25 min under carbon dioxide atmosphere, followed by the sequential addition of toluene (8 mL), 3-bromoquinoline (1.0 mmol), Pd(OAc)2 (0.03 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyloxanthene (0.06 mmol), Et3N (2.5 mmol, 2.5 equiva.) and then Carbon dioxide was removed and the reaction was carried out at 100 C until the raw material bromobenzene disappeared, cooled to room temperature and then sodium hydroxide solution (1M, 10.0 mL) was added, stirred for 10 min and then filtered, the solids were washed with water for 3 times, the filtrate was extracted with ethyl acetate (2 x 10 mL) leaving an aqueous layer, the aqueous layer was adjusted to pH 1-2 with hydrochloric acid solution (1 M), extracted with ethyl acetate (3 x 15 mL) and Anhydrous sodium sulfate was dried, and the solvent was removed to obtain quinoline-3-carboxylic acid in 98% yield.

3-Quinolinecarboxylic acid(6480-68-8)Related Product Information

• Isoquinoline
• Hyaluronic acid
• Ethoxyquin
• 8-Hydroxyquinoline
• 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
• QUINOLINE SULPHATE
• Quinoline
• Quinaldic acid
• Quinhydrone
• Folic acid
• Stearic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Quinclorac
• QUINOLINE-4-CARBOXYLIC ACID
• 2-METHYL-3-HYDROXY-QUINOLINE-4-CARBOXYLIC ACID
• 6-Quinolinecarboxylic acid
• Quinoline-5-carboxylic acid
• Citric acid