jnj39758979
jnj39758979 Basic information
- Product Name:
- jnj39758979
- Synonyms:
-
- jnj39758979
- 4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE
- JNJ 39758979 (JNJ-39758979
- 2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-
- (R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine
- agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979
- JNJ-39758979, 10 mM in DMSO
- CAS:
- 1046447-90-8
- MF:
- C11H19N5
- MW:
- 221.3
- Mol File:
- 1046447-90-8.mol
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jnj39758979 Chemical Properties
- storage temp.
- 4°C, protect from light
- solubility
- Chloroform (Slightly), DMSO (Slightly, Sonicated)
- form
- Solid
- color
- Pale Beige to Light Beige
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jnj39758979 Usage And Synthesis
Uses
JNJ 39758979, is a selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM.
in vivo
JNJ-39758979 (10 mg/kg; p.o.) treatment shows that the Cmax, t1/2 and F values are 0.3 μM, 7.5 hours, and 36%, respectively[1].
JNJ-39758979 (2 mg/kg; i.v.) treatment shows that the Vss, AUC, CL and t1/2 were 19.9 L/kg, 1.4 μM*h, 2.2 L/h, and 2.1 hours, respectively [1].
| Animal Model: | Sprague-Dawley rats[1] |
| Dosage: | 10 mg/kg |
| Administration: | Oral administration (Pharmacokinetic Analysis) |
| Result: | The Cmax, t1/2 and F values were 0.3 μM, 7.5 hours, and 36%, respectively. |
IC 50
Human H4 Receptor: 12.5 nM (Ki); Mouse H4 Receptor: 5.3 nM (Ki); Monkey H4 receptor: 25 nM (Ki); Rat H4 receptor: 188 nM (Ki); Guinea pig H4 receptor: 306 nM (Ki)
jnj39758979Supplier
Nanjing Chemlin Chemical Co., Ltd
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- 025-83697070
- info@chemlin.com.cn
Taizhou Tongxin Bio-Tech Co., Ltd
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- 0523-86818997 18652728585
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Shanghai Chaolan Chemical Technology Center
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- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com