M348 Chemical Properties

Boiling point:

546.2±50.0 °C(Predicted)

Density 

1.422±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)

form 

Powder

pka

13.13±0.70(Predicted)

M348 Usage And Synthesis

Uses

ML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

storage

Store at +4°C

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