M348 Chemical Properties

Boiling point:

546.2±50.0 °C(Predicted)

Density 

1.422±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)

form 

Powder

pka

13.13±0.70(Predicted)

color 

White to off-white

M348 Usage And Synthesis

Uses

ML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

storage

Store at +4°C

M348(899713-86-1)Related Product Information

• Nodinitib-1
• 9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl-
• ML188
• ML418
• [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• ML213
• N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
• PTP1B-IN-2
• ML264
• ML216
• ML385
• ML365
• ML 141
• ML355
• ml390
• (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
• 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
• ML277