Azide-PEG12-Tos
Azide-PEG12-Tos Basic information
- Product Name:
- Azide-PEG12-Tos
- Synonyms:
-
- Azide-PEG12-Tos
- N3-PEG12-Tos
- 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
- Azido-PEG12-Tos
- Azide PEG12 Tos,AzidePEG12Tos,Inhibitor,Azide-PEG-12-Tos,PROTAC Linkers,inhibit
- N3-PEG12-Tos/3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontan-1-ol, 35-azido-, 1-(4-methylbenzenesulfonate)
- 35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl 4-methylbenzenesulfonate
- CAS:
- 1821464-56-5
- MF:
- C31H55N3O14S
- MW:
- 725.85
- Mol File:
- 1821464-56-5.mol
Azide-PEG12-Tos Chemical Properties
- solubility
- Soluble in DMSO, DCM, DMF
Azide-PEG12-Tos Usage And Synthesis
Description
Azide-PEG12-Tos is a monodisperse PEG reagent containing an azide group and a tosyl group. Long PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic reactions.
Uses
Azide-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG12-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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