CONDURITOL B EPOXIDE Chemical Properties

Melting point:

157-159

Boiling point:

360.5±42.0 °C(Predicted)

Density 

1.925±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

solubility 

Soluble in Water (up to 25 mg/ml) or in DMSO

pka

13.08±0.70(Predicted)

form 

White solid

color 

White

biological source

synthetic (organic)

Water Solubility 

water: 20mg/mL, clear, colorless to faintly yellow

Stability:

Moisture Sensitive

InChI

InChI=1/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/s3

InChIKey

ZHMWOVGZCINIHW-OUIPVDLDNA-N

SMILES

[C@H]12O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H]2O |&1:0,2,3,5,7,9,r|

Safety Information

WGK Germany 

3

Hazard Note 

Harmful

HS Code 

2932990090

MSDS

• Language:English Provider:SigmaAldrich

CONDURITOL B EPOXIDE Usage And Synthesis

Description

Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4.

Chemical Properties

White Crystalline Solid

Uses

inhibitor of glucosidases

Definition

ChEBI: 1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It is functionally related to a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol.

General Description

Conduritol B epoxide?(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.

Biochem/physiol Actions

Conduritol B epoxide?(CBE)?is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).

storage

Store at -20°C

References

[1] SUBHASH C. DATTA  Norman S R. Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection[J]. Biochemical and biophysical research communications, 1988, 152 1: Pages 155-160. DOI:10.1016/s0006-291x(88)80693-4
[2] N S RADIN  R R V. Inhibitors of cerebroside metabolism.[J]. Methods in enzymology, 1981, 72: 673-684. DOI:10.1016/s0076-6879(81)72057-3
[3] M.CARLA STEPHENS . Distribution of conduritol B epoxide in the animal model for Gaucher’s disease (Gaucher mouse)[J]. Biochimica et biophysica acta. General subjects, 1981, 672 1: Pages 29-32. DOI:10.1016/0304-4165(81)90276-2
[4] DAVID S. NEWBURG. β-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986, 877 1: Pages 121-126. DOI:10.1016/0005-2760(86)90126-8

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