CP671305 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 2 mg/ml

form 

A crystalline solid

CP671305 Usage And Synthesis

Description

CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC₅₀ = 3 nM). It is selective for PDE4D over PDE4A, -B, and -C (IC₅₀s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC₅₀s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E₄ (LTE₄; ) from eosinophils (IC₅₀ = 52 nM) and LTB₄ from neutrophils (IC₅₀ = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.

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