2-Thiophenemethylamine Chemical Properties

Boiling point:

95-99 °C/28 mmHg (lit.)

Density 

1.103 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.5670(lit.)

Flash point:

165 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Easily soluble in ethanol and Chloroform.

pka

8.95±0.29(Predicted)

form 

liquid

color 

Clear colorless to yellow

Sensitive 

Air Sensitive

BRN 

106296

InChIKey

FKKJJPMGAWGYPN-UHFFFAOYSA-N

CAS DataBase Reference

27757-85-3(CAS DataBase Reference)

NIST Chemistry Reference

2-Thiophenemethanamine(27757-85-3)

EPA Substance Registry System

2-Thiophenemethylamine (27757-85-3)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-27-36/37/39-45-25

RIDADR 

UN 3267 8/PG 2

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

III

HS Code 

29349990

MSDS

• Language:English Provider:2-(Aminomethyl)thiophene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Thiophenemethylamine Usage And Synthesis

Chemical Properties

Clear yellow liquid

Uses

2-Thiophenemethylamine can be used as areactant involved in synthesis of Triazole-linked-thiopene conjugates and a biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein.

Uses

2-Thiophenemethylamine is Reactant involved in synthesis of: Triazole-linked-thiopene conjugates. It is used for biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein.It is a reactant involved in studies of organocatalyzed asymmetric reductive amination of ketones.

Uses

Reactant involved in synthesis of:

• Triazole-linked-thiopene conjugates for use as a biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein
• Serotonin 5-HT1A receptor antagonists which have neuroprotective affects against ischemic cell damage
• Imidazole- and piperonyl-containing thiadiazoles and pyrimidines for use as inducible oxide synthase dimerization inhibitors
• Optoelectronic segmented polyurethanes

• Studies of organocatalyzed asymmetric reductive amination of ketones
• Metal-free aerobic oxidative coupling of amines to imines

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1389, 1946 DOI: 10.1021/ja01211a510

General Description

2-Thiophenemethylamine is a potential ligand replacement for poly(3-hexylthiophene)/CdSe hybrid solar cells.

Purification Methods

Distil the amine under reduced pressure (nitrogen), from BaO, through a column packed with glass helices. The hydrochloride has m 193-194o (from EtOH/Me2CO) and the picrate has m 181-182o. [Beilstein 18 III/IV 7096.]

2-Thiophenemethylamine(27757-85-3)Related Product Information

• Meglumine
• 2-Thiophenecarboxylic acid
• trimethylamine oxide
• Thiophene
• SILIBININ-N-METHYLGLUCAMINE, 95％ （HPLC）
• Trimethylamine
• Flunixin meglumine
• Cephalothin sodium
• Tetrahydrothiophene
• Methylamine
• 2-THIOPHENECARBOXAMIDE
• 5-[(BENZOYLAMINO)METHYL]THIOPHENE-2-SULFONYL CHLORIDE
• 3-AMINOTHIOPHENE-2-CARBOXAMIDE
• 2-(Thien-2-yl)pyrrolidine
• 2-Thiophenecarboxylic acid hydrazide
• AMINO-THIOPHEN-2-YL-ACETIC ACID
• METHAPYRILENE HYDROCHLORIDE
• THIOPHENE-2-THIOCARBOXAMIDE