HC≡C-CH2-PEG6-SH Usage And Synthesis

Uses

Propargyl-PEG6-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG6-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

Propargyl-PEG6-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HC≡C-CH2-PEG6-SH(1422540-91-7)Related Product Information

• Propargyl-PEG5-alcohol
• Propargyl-PEG6-methylamine
• mPEG5-Propyne
• Propargyl-PEG6-acid
• Propargyl-PEG6-Maleimide
• Propargyl-PEG5-tetra-Ac-beta-D-galactose
• Propargyl-PEG4-Sulfone-PEG4-acid
• Propargyl-PEG4-S-PEG4-acid
• Propargyl-PEG1-SS-PEG1-PFP ester
• Propargyl-PEG4-(CH2)3-acid
• Propargyl-PEG1-SS-alcohol
• Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
• Propargyl-PEG4-S-PEG4-Propargyl
• Propargyl-PEG8-bromide
• Propargyl-PEG1-SS-PEG1-propargyl
• Propargyl-PEG4-sulfonic acid
• Propargyl-PEG9-bromide
• Propargyl-PEG5-beta-D-galactose