HC≡C-CH2-PEG6-SH
HC≡C-CH2-PEG6-SH Basic information
- Product Name:
- HC≡C-CH2-PEG6-SH
- Synonyms:
-
- HC≡C-CH2-PEG6-SH
- Propargyl-PEG6-SH
- 3,6,9,12,15,18-Hexaoxaheneicos-20-yne-1-thiol
- 3,6,9,12,15,18-hexaoxahenicos-20-yne-1-thiol
- CAS:
- 1422540-91-7
- MF:
- C15H28O6S
- MW:
- 336.44
- Product Categories:
-
- peg
- Mol File:
- 1422540-91-7.mol
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HC≡C-CH2-PEG6-SH Usage And Synthesis
Biological Activity
Propargyl-PEG6-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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