Squalene Chemical Properties

Melting point:

−75 °C(lit.)

Boiling point:

285 °C25 mm Hg(lit.)

Density 

0.858 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.494(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

liquid

color 

light yellow

Cosmetics Ingredients Functions

HAIR CONDITIONING
SKIN CONDITIONING - EMOLLIENT
SOLVENT

InChI

InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3

InChIKey

YYGNTYWPHWGJRM-UHFFFAOYSA-N

SMILES

C/C(/C)=C\CCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CC/C=C(/C)\C

LogP

12.188 (est)

NIST Chemistry Reference

Squalene(7683-64-9)

EPA Substance Registry System

Spinacene (7683-64-9)

Safety Information

Safety Statements 

24/25

WGK Germany 

2

RTECS 

XB6010000

F 

8-10-23

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Squalene Usage And Synthesis

Chemical Properties

Squalene belongs to the group of triterpenoids. Oily liquid. After absorbing oxygen in the air, it is transformed into viscous liquid resembling linseed oil. Melting point -38 ° C, boiling point 280 ° C (17 mm Hg), specific gravity 0.8128 (15/4 ° C), refractive index 1.4965, in cyclohexane UV λmax < 226 nm. Soluble in ether, petroleum ether, acetone and carbon tetrachloride and other fat-soluble solvents, slightly soluble in ethanol and glacial acetic acid, almost insoluble in water. Has a slight pleasant odor. Decomposes when distilled under normal pressure. Gradually absorbs oxygen and resinates when placed in air.

Uses

squalene is like squalane, squalene replenishes skin lipids while softening and smoothing. It helps maintain the skin in good condition. When used in hair care products, it serves as a hairconditioning and anti-static agent.

Uses

Spinacene can be used for its antioxidant properties using its essential oils derived from its leaves and stem, including, effective larvacides

Definition

squalene: An intermediate compoundformed in the synthesis ofcholesterol; it is a hydrocarbon containing30 carbon atoms. The immediateoxidation of squalene tosqualene 2,3-epoxide is the last commonstep in the synthesis of sterolsin animals, plants, and fungi.

Synthesis

Squalene is generally extracted from shark liver oil by distillation. Pure squalene at atmospheric pressure 350 ?? C boiling, and partially decomposed, therefore, must be distilled under reduced pressure, or liver oil direct distillation, or first saponification of liver oil, will not be saponified for distillation. Now give an example of direct distillation: 170 ml of liver oil for decompression distillation, when the internal temperature of 85 ~ 140 ??, the vacuum degree of 6 ~ 1.2Pa, the first fraction began to appear, this is a yellow oily, about 40 ml. When the internal temperature rises to 190 ~ 206 ??, the vacuum degree of 0.8 ~ 0.4Pa, the collection of the second fraction, about 78 ml. will be the second fraction of yellow oily for the Decompression fractional distillation, when the internal temperature was 190 ?? and the vacuum degree was 0.53 Pa, about 20 ml of light yellow oily material appeared. When the temperature was increased to 195-200??C and the vacuum degree was 0.4-0.13 Pa, about 35 ml of colorless transparent oily material was collected, which was squalene

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