Lanoconazole
Lanoconazole Basic information
- Product Name:
- Lanoconazole
- Synonyms:
-
- LANOCONAZOLE
- [4-(2-chloro-phenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile
- (+-)-(e)-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-1-imidazolylacetonitri
- (e)-alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-1h-imidazole-1-aceton
- 1h-imidazole-1-acetonitrile,alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)
- (E)-alpha-(4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene)-1H-imidazole-1-acetonitrile
- 1H-Imidazole-1-acetonitrile, alpha-(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-, (E)-(+-)
- (E)-2-[4-(2-Chlorophenyl)-1,3-dithiolane-2-ylidene]-2-(1-imidazolyl)acetonitrile
- CAS:
- 101530-10-3
- MF:
- C14H10ClN3S2
- MW:
- 319.83
- EINECS:
- 635-180-5
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 101530-10-3.mol
Lanoconazole Chemical Properties
- Melting point:
- 141.50C
- Boiling point:
- 477.6±55.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.76±0.10(Predicted)
- color
- White
- CAS DataBase Reference
- 101530-10-3(CAS DataBase Reference)
MSDS
- Language:English Provider:[4-(2-Chloro-phenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile
Lanoconazole Usage And Synthesis
Description
Lanoconazole is a potent antifungal imidazole launched in Japan for the treatment of dermal mycoses. Lanoconazole is reported to be an inhibitor of ergosterol biosynthesis thus altering the ultra structure of the cell wall. It exhibits potent antifungal activity against a wide range of pathogenic fungi including yeast, dermatophytes, dermatiaceous fungi, dimorphic fungi, Aspergihs spp., Penici//ium spp., and Candida spp., being particularly active against Trichophyton spp.. It is considerably more potent than other agents of the same family such as bifonazole and clotrimazole. Clinical efficacy was demonstrated by remarkable improvements in skin symptoms of the patients with tinea pedis, tinea corporis and cruis, candidiasis or tinea versicolor.
Chemical Properties
Light-Yellow Crystals
Originator
Nihon Nohyaku (Japan)
Uses
Antifungal.
Definition
ChEBI: Lanoconazole is a conazole antifungal drug and an imidazole antifungal drug.
brand name
Astat
Lanoconazole Preparation Products And Raw materials
Raw materials
LanoconazoleSupplier
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