GNE-955
GNE-955 Basic information
- Product Name:
- GNE-955
- Synonyms:
-
- GNE-955
- GNE-955( 5-Azaindazole)
- GNE955,GNE 955
- 3-Piperidinamine, 1-[3-methoxy-6-[6-(6-methyl-2-pyrazinyl)-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-pyridinyl]-, (3S)-
- (3S)-1-[3-Methoxy-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]pyridin-2-yl]piperidin-3-amine
- CAS:
- 1527523-39-2
- MF:
- C22H24N8O
- MW:
- 416.48
- Mol File:
- 1527523-39-2.mol
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GNE-955 Chemical Properties
- Boiling point:
- 615.2±55.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.90±0.20(Predicted)
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GNE-955 Usage And Synthesis
Description
GNE-955 is a Potent Pan-Pim Inhibitor. GNE-955 is potent and has excellent bioavailability in rat.
Uses
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
IC 50
PIM1: 0.018 nM (Ki); PIM2: 0.11 nM (Ki); PIM3: 0.08 nM (Ki)
References
[1] Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60(10):4458-4473. DOI:10.1021/acs.jmedchem.7b00418
GNE-955Supplier
Chembest Research Laboratories Limited
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- +86-21-20908456
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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- 028-81700200 18116577057
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Fan De(Beijing) Biotechnology Co., Ltd.
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- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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- 86-571-88216897,88216896 13588875226
- sales@hzclap.com