Basic information Safety Supplier Related

VU 6008667

Basic information Safety Supplier Related

VU 6008667 Basic information

Product Name:
VU 6008667
Synonyms:
  • VU 6008667
  • 5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)-
CAS:
2092923-21-0
MF:
C24H17ClF2N2O2
MW:
438.85
Mol File:
2092923-21-0.mol
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VU 6008667 Chemical Properties

Boiling point:
616.1±55.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mg/mL (227.87 mM)
pka
-2.76±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
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VU 6008667 Usage And Synthesis

Uses

VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration[1].

in vivo

VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t1/2=2.3 hr) driven by a smaller volume (Vss=7.4 L/kg) and higher clearance (CLp=82 mL/min/kg), with moderate oral bioavailability (17% F)[1].

Animal Model:RAT (PK study)[1]
Dosage:1 mg/kg; 3 mg/kg
Administration:oral adminstration
Result:Had a desired short half-life in rat (t1/2= 2.3 hr), with moderate oral bioavailability (17% F).

IC 50

mAChR5

References

[1] McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. DOI:10.1016/j.bmcl.2017.02.020

VU 6008667Supplier

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
BOC Sciences
Tel
Email
info@bocsci.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Email
sales@chemegen.com
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VU 6008667(2092923-21-0)Related Product Information