Fmoc-Val-Ala-PAB-OH
Fmoc-Val-Ala-PAB-OH Basic information
- Product Name:
- Fmoc-Val-Ala-PAB-OH
- Synonyms:
-
- CS-2746
- Fmoc-Val-ala-PAB
- Fmoc-Val-Ala-PAB-OH, 9-fluorenylmethyloxycarbonyl-valyl-alanyl-4-aminobenzylalcohol
- L-Alaninamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-
- Fmoc-Val-Ala-PAB-OH
- (9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
- 1-Butanesulfonicacid,6-hydroxy-
- Inhibitor,Antibody-drug conjugates linkers,ADC Linkers,Fmoc Val Ala PAB OH,inhibit,FmocValAlaPABOH
- CAS:
- 1394238-91-5
- MF:
- C30H33N3O5
- MW:
- 515.6
- Product Categories:
-
- Linker
- ADCs Linkers
- ADCs
- ADC LINKER
- ADC-Linker
- Mol File:
- 1394238-91-5.mol
More
Less
Fmoc-Val-Ala-PAB-OH Chemical Properties
- Melting point:
- 218 °C(dec.)
- Boiling point:
- 811.1±65.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- solubility
- DMSO : 33.33 mg/mL (64.64 mM; ultrasonic and warming and heat to 80°C)
- pka
- 10.63±0.46(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
More
Less
Fmoc-Val-Ala-PAB-OH Usage And Synthesis
Description
Fmoc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.
Uses
Fmoc-Val-Ala-PAB is a building block used in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.
Fmoc-Val-Ala-PAB-OHSupplier
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. Gold
- Tel
- 13414494621
- chenchao02lzu@126.com
SuZhou JianHua Pharmaceutical Co. Ltd Gold
- Tel
- 13666392288
- jhyylcj@163.com
Hygeia (Chengdu) pharmaceutical technique Co., Ltd Gold
- Tel
- 028-84502008 13568869383
- sales@hygeiapharm.com
TOKYO CHEMICAL INDUSTRY CO., LTD.
- Tel
- 03-36680489
- Sales-JP@TCIchemicals.com
TCI Europe
- Tel
- 320-37350700
- sales@tcieurope.eu