FmocNH-PEG12-CH2CH2COOH Chemical Properties

Boiling point:

870.4±65.0 °C(Predicted)

Density 

1.175±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

form 

clear liquid

color 

Colorless to Light yellow

InChIKey

JYNHRDJTWNEGJE-UHFFFAOYSA-N

SMILES

C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

Safety Information

HS Code 

2924297099

FmocNH-PEG12-CH2CH2COOH Usage And Synthesis

Description

Fmoc-N-amido-PEG12-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

General Description

FmocNH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker. Fmoc-NH-PEG12-CH2CH2COOH can be used in the synthesis of PROTAC.

storage

Keep in dark place,Inert atmosphere,Store in freezer, under -20 ℃.