6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride Chemical Properties

Melting point:

198-202 °C

RTECS 

NW7625000

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale yellow

Water Solubility 

soluble

InChI

InChI=1S/C11H13NO2.ClH/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2;/h5-7H,3-4H2,1-2H3;1H

InChIKey

PQXVEYYRJHMTEV-UHFFFAOYSA-N

SMILES

C12CCN=CC=1C=C(OC)C(OC)=C2.Cl

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

HS Code 

29334990

MSDS

• Language:English Provider:6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride
• Language:English Provider:ACROS

6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride Usage And Synthesis

Chemical Properties

light yellow to yellow crystalline powder

Uses

6,7-Dimethoxy-3,4-dihydroisoquinoline is used in the synthesis of Tetrabenazine (T284000).

Uses

6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride is used in the synthesis of Tetrabenazine (T284000).

Synthesis

First, 3,4-dimethoxyphenethylamine (18.1 g, 0.1 mol) and ethyl formate (22.1 g) were added to a 100 mL three-necked flask protected by nitrogen, and the reaction was held at 60 ??C with stirring for 24 hours. Decompression and concentration to obtain N-(3,4-dimethoxyphenethyl)formamide crude product. The above crude product was dissolved in 180 mL of dichloromethane, phthaloyl dichloride (20.3 g, 0.1 mol) was added, and the reaction was stirred at 20??C for 4 h. The solid was gradually precipitated. Cooled to 10 ??, filtered to obtain 6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride crude product (mother liquor was washed twice with 50mL water, concentrated to recover dichloromethane, the residue was added to 100mL water, filtered to recover phthalic anhydride). Add the above crude product to isopropanol (180mL), heating to 70 ??, stirring 0.5-1h until all the solids are dissolved; add activated charcoal 1.8g, 80 ?? continue to stir for 2-3h, 50 ?? keep warm and filtration, filtrate re-warming to 70 ??, stirring for 0.5h; naturally cooled to 20 ??, it takes about 2h, filtration to get 6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride The finished product was 19.0 g. Yield 83%, HPLC purity 99.61%.

6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride(20232-39-7)Related Product Information

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