3-(4-Nitrophenyl)-beta-alanine Chemical Properties

Melting point:

226 °C (decomp)

Boiling point:

410.3±40.0 °C(Predicted)

Density 

1.404±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.50±0.10(Predicted)

Appearance

White to light yellow Solid

CAS DataBase Reference

102308-62-3(CAS DataBase Reference)

3-(4-Nitrophenyl)-beta-alanine Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-amino-3-(4-nitrophenyl)propionic acid from malonic acid and p-nitrobenzaldehyde: A mixture of 2.40 g of p-nitrobenzaldehyde, 2.44 g of malonic acid, and 3.54 g of ammonium acetate (molar ratio 1:1.1:2.3) was dissolved in 200 mL of 1 -butanol, and the reaction was carried out at reflux for 1.5-2 hr until the release of carbon dioxide gas stopped. Upon completion of the reaction, the precipitate formed was filtered and washed sequentially with boiling 1-butanol (2 x 50 mL), boiling ethanol (2 x 50 mL) and 100 mL of water. The precipitate was dried at 80-100°C for 8-10 hours. The purity of the product was checked by thin layer chromatography (TLC) and the reaction yield was about 65-80%.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 252 - 268

3-(4-Nitrophenyl)-beta-alanine(102308-62-3)Related Product Information

• 3-(4-Nitrophenyl)-beta-alanine
• (S)-3-(3-NITROPHENYL)-BETA-ALANINE
• (R)-3-(P-NITROPHENYL)-BETA-ALANINE
• 3-(2-NITROPHENYL)-BETA-ALANINE
• (R)-3-(3-NITROPHENYL)-BETA-ALANINE
• (S)-3-(P-NITROPHENYL)-BETA-ALANINE
• BOC-(S)-3-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID
• 2-CYCLOPENTYL-3-(4-NITROPHENYL)-1-OXO-1,2,3,4-TETRAHYDRO-4-ISOQUINOLINECARBOXYLIC ACID
• 6-METHYL-4-(4-NITRO-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• 3-(ACETYLAMINO)-3-(4-NITROPHENYL)PROPANOIC ACID
• (R)-3-BOC-AMINO-3-(4-NITROPHENYL)PROPIONIC ACID
• 3-TERT-BUTOXYCARBONYLAMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID
• (S)-3-(2-NITROPHENYL)-BETA-ALANINE
• (R)-3-(2-NITROPHENYL)-BETA-ALANINE
• (S)-N-FMOC-beta-(3-nitrophenyl)-beta-alanine
• N-(4-nitrophenyl)-beta-alanine
• RARECHEM AK HW 0202
• 1,6-DIMETHYL-4-(4-NITRO-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER