N-Stearoyl-phytosphingosine Chemical Properties

Melting point:

122-124°C

Boiling point:

718℃ at 10hPa

Density 

0.994-1.014 at 20℃

vapor pressure 

0Pa at 25℃

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform : Methanol = 3 : 1 (Slightly), Pyridine (Slightly, Heated, Sonicated)

form 

Solid

color 

White to Off-White

InChIKey

IEZRNEGTKRQRFV-LFBNJJMOSA-N

SMILES

C(N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)(=O)CCCCCCCCCCCCCCCCC

LogP

12.01 at 25℃ and pH7

N-Stearoyl-phytosphingosine Usage And Synthesis

Description

N-Stearoyl-phytosphingosine (SPS), sphingolipids frequently found in mammalian skin, plants, and yeast, have been used in cosmetics. In mice, treatment with SPS inhibited histamine-induced scratching behavior and vascular permeability. This agent inhibited the expression of the allergic cytokines IL-4 and TNF-a and the activation of the transcription factors NF-jB and c-jun in histamine-stimulated skin tissues[1].

Uses

An intercellular lipid that benefits skin hydration and protects against SLS irritation.

Definition

ChEBI: N-octadecanoyl-4-hydroxysphinganine is a phytoceramide in which the ceramide N-acyl group is specified as octadecanoyl (stearoyl). It is a N-acylphytosphingosine and a N-stearoyl-sphingoid base.

References

[1] Kwon-Ryeol Ryu. “Anti-scratching Behavioral Effects of N-Stearoyl-phytosphingosine and 4-Hydroxysphinganine in Mice.” Lipids 45 7 (2010): 613–618.

N-Stearoyl-phytosphingosine(34354-88-6)Related Product Information

• Sodium stearyl lactate
• Phytosphingosine