Prednicarbate Chemical Properties

Melting point:

110-112°; mp 183°

alpha 

D20 +63° (c = 0.1 in ethanol)

Boiling point:

640.7±55.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), sparingly soluble in propylene glycol. It shows polymorphism (5.9).

pka

14.05±0.70(Predicted)

form 

Solid

color 

White to Off-White

InChIKey

FNPXMHRZILFCKX-IVRISGIPNA-N

SMILES

[C@@]1(OC(=O)OCC)(C(=O)COC(=O)CC)CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C |&1:0,17,19,29,31,33,36,r|

Safety Information

HS Code 

2937290000

MSDS

• Language:English Provider:[2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate

Prednicarbate Usage And Synthesis

Description

Prednicarbate is a potent topical antiinflammatory agent with minimal systemic effects. It is useful in the treatment of cutaneous inflammatory disorders such as eczema and psoriasis.

Description

Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone . It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice. Formulations containing prednicarbate have been used to treat chronic hand eczema.

Chemical Properties

White or almost white, crystalline powder.

Originator

Hoechst AG (W. Germany)

Uses

Topical anti-inflammatory agent. Glucocorticoid.
Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.

Indications

Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.

Definition

ChEBI: Prednicarbate is a corticosteroid hormone.

brand name

Dermatop (Sanofi Aventis).

General Description

Prednicarbate, 17-[(ethoxycarbonyl)oxy]-11β-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione, is a prednisolone derivative with a C21 propionateester and a C17 ethyl carbonate group. It is availablefor use only in a 0.1% topical cream. Prednicarbate is amedium-potency GC.

References

[1] H G ALPERMANN  H G V  J Sandow. [Animal experiment studies on the topical and systemic effectiveness of prednisolone-17-ethylcarbonate-21-propionate].[J]. Zeitschrift fur Hautkrankheiten, 1986, 61 Suppl 1: 7-17.
[2] NICHOLAS S. BODOR  Laszlo B  Susan Tatar Kiss Buns. Novel soft steroids: effects on cell growth in vitro and on wound healing in the mouse[J]. Steroids, 1991, 56 8: Pages 434-439. DOI: 10.1016/0039-128x(91)90032-q
[3] STEPHANIE SOOST. Topical therapy of hand eczema – analysis of the prescription profile from dermatologists in private practice[J]. Journal Der Deutschen Dermatologischen Gesellschaft, 2011, 10 3: 180-184. DOI: 10.1111/j.1610-0387.2011.07787.x

Prednicarbate(73771-04-7)Related Product Information

• 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
• Clindamycin 4-Phosphate
• Ambroxol hydrochloride
• N-Deformyl-N-pivaloyl Orlistat
• 10-Propargyl-10-deazaaminopterin
• Cilastatin
• Esmolol Impurity 2 HCl
• (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethanone
• AMbroxol EP IMpurity D
• GATIFLOXACIN RELATED COMPOUND A
• Eflone
• Prednisolone-21-acetate
• Prednicarbate
• Prednicarbate Related Compound A
• Prednicarbate Related Compound C
• Prednicarbate Related Compound B
• Prednisolone
• prednisolone 17-ethylcarbonate