4-Chloro-3-fluoroaniline Chemical Properties

Melting point:

61

Boiling point:

226°C(lit.)

Density 

1.349±0.06 g/cm3(Predicted)

Flash point:

60 - 62°C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

2.94±0.10(Predicted)

color 

White to Gray to Red

BRN 

2716278

CAS DataBase Reference

367-22-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39-63-45-38

RIDADR 

UN2811

WGK Germany 

3

Hazard Note 

Toxic

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214200

4-Chloro-3-fluoroaniline Usage And Synthesis

Uses

4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib.

Chemical Properties

White to light yellow solid

Uses

4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate

4-Chloro-3-fluoroaniline(367-22-6)Related Product Information

• Chlorpropham
• 4-Chloroaniline
• 4-Fluoroaniline
• 2-Fluoroaniline
• 3-Chloroaniline
• 4-(Trifluoromethoxy)aniline
• 3-Fluoroaniline
• 2-Chloroaniline
• 3-Aminobenzotrifluoride
• Epichlorohydrin
• 4-Chloro-3-fluoronitrobenzene
• 3-Chloro-2-fluoroaniline97%,3-CHLORO-2-FLUOROANILINE,3-Chloro-2-fluoroaniline 97%
• 4-(3-Chloropropyl)morpholine
• Isovanillin
• Benzonitrile, 5-methoxy-4-[3-(4-morpholinyl)propoxy]-2-nitro-
• 3-Chloro-4-fluoronitrobenzene
• Benzonitrile, 5-hydroxy-4-methoxy-2-nitro-
• Benzonitrile, 2-amino-5-methoxy-4-[3-(4-morpholinyl)propoxy]-