BOC-LYS(AC)-OH HCL Chemical Properties

Boiling point:

374.7±37.0 °C(Predicted)

Density 

1.056±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

11.16±0.46(Predicted)

Appearance

colorless oil or crystal

CAS DataBase Reference

55757-60-3(CAS DataBase Reference)

BOC-LYS(AC)-OH HCL Usage And Synthesis

Chemical Properties

Colorless to light yellow oil

Uses

Boc-L-Lysine Methyl Ester is a reagent in the synthesis of myxochelin analogs as antimetastatic agents.

Synthesis

General procedure for the synthesis of (S)-6-amino-2-((tert-butoxycarbonyl)amino)hexanoic acid methyl ester from (S)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid: intermediate 4 (839 mg, 2.1 mmol) was dissolved in methanol (15 mL). After addition of catalytic amount of Pd/C, the reaction was stirred under hydrogen atmosphere and room temperature for 40 min. The completion of the reaction was monitored by thin-layer chromatography (TLC, unfolding reagent ratio of ethyl acetate:hexane = 2:1). After completion of the reaction, the reaction solution was filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give Intermediate 5 (563 mg, quantitative yield) as a colorless oil, which can be used in subsequent reactions without further purification.

References

[1] Patent: US2015/80551, 2015, A1. Location in patent: Paragraph 0047
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 6, p. 1643 - 1647
[3] Angew. Chem., 2017, vol. 129, # 6, p. 1665 - 1669,5
[4] Tetrahedron, 1982, vol. 38, p. 697
[5] Chemistry - A European Journal, 2011, vol. 17, # 18, p. 5011 - 5018

BOC-LYS(AC)-OH HCL(55757-60-3)Related Product Information

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