Cyclophosphamide monohydrate Chemical Properties

Melting point:

49-51 °C (lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

H₂O: 0.1 g/mL, clear, colorless

form 

Crystals or Crystalline Powder

color 

White to almost white

Water Solubility 

40 g/L

Merck 

14,2747

BRN 

8167897

Stability:

Hygroscopic

InChIKey

PWOQRKCAHTVFLB-UHFFFAOYSA-N

CAS DataBase Reference

6055-19-2(CAS DataBase Reference)

IARC

1 (Vol. 26, Sup 7, 100A) 2012

EPA Substance Registry System

Cyclophosphamide monohydrate (6055-19-2)

Safety Information

Hazard Codes 

T

Risk Statements 

45-25-61-46-36/37/38-23/24/25

Safety Statements 

53-45-37/39-26

RIDADR 

UN 3464 6.1/PG 3

WGK Germany 

3

RTECS 

RP6157750

F 

10

HazardClass 

6.1

PackingGroup 

II

HS Code 

29349990

MSDS

• Language:English Provider:N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester amide monohydrate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Cyclophosphamide monohydrate Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Uses

antineoplastic, alkylating agent

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.

Uses

alkylating agent in cancer therapy

Definition

ChEBI: The monohydrate of cyclophosphamide.

brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Fire Hazard

Cyclophosphamide monohydrate is probably combustible.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.

Cyclophosphamide monohydrate(6055-19-2)Related Product Information

• MELIBIOSE
• NITRIC OXIDE
• Polyamide
• Rink Amide Linker
• BUTYL OLEATE
• Dibenzylamine
• Tris(trimethylsilyl)phosphate
• Methyl acrylate
• Bis(2-ethylhexyl)amine
• Triallylamine
• Ethylcyclohexane
• Fomesafen
• (Diethoxymethyl)diphenylphosphine oxide
• Ifosfamide
• Cyclophosphamide
• Mafosfamide
• 4-HYDROPEROXY CYCLOPHOSPHAMIDE
• IFOSFAMIDE IMPURITY F