2-METHYLGLUTARONITRILE Chemical Properties

Melting point:

−45 °C(lit.)

Boiling point:

269-271 °C(lit.)

Density 

0.95 g/mL at 25 °C(lit.)

vapor pressure 

1.9Pa at 20℃

refractive index 

n20/D 1.434(lit.)

Flash point:

>230 °F

storage temp. 

Store at +2°C to +8°C.

solubility 

water: soluble

form 

clear liquid

color 

Colorless to Light yellow to Light orange

explosive limit

0.3-3.25%(V)

Water Solubility 

52.3g/L at 20℃

BRN 

1741955

InChIKey

FPPLREPCQJZDAQ-UHFFFAOYSA-N

LogP

0.46 at 20℃

CAS DataBase Reference

4553-62-2(CAS DataBase Reference)

EPA Substance Registry System

2-Methylglutaronitrile (4553-62-2)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

20/21/22-23/25-21

Safety Statements 

36/37-45-36/37/39

RIDADR 

3276

WGK Germany 

3

RTECS 

YV8140000

HS Code 

2926.90.5050

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

4553-62-2(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich

2-METHYLGLUTARONITRILE Usage And Synthesis

Uses

2-Methylglutaronitrile (MGN) may be used in the synthesis of 1,5-dimethyl-2-piperidone (1,5-DMPD) by chemoenzymatic process.

General Description

Amber liquid.

Air & Water Reactions

Water soluble.

Reactivity Profile

Nitriles, such as 2-METHYLGLUTARONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Health Hazard

ACUTE/CHRONIC HAZARDS: 2-METHYLGLUTARONITRILE is readily absorbed through the skin.

Fire Hazard

2-METHYLGLUTARONITRILE is combustible.

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