4-Amino-2-chlorobenzonitrile Chemical Properties

Melting point:

116-118 °C(lit.)

Boiling point:

339.5±27.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

0.67±0.10(Predicted)

color 

White to Light yellow to Light orange

BRN 

2936425

CAS DataBase Reference

20925-27-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi,N

Risk Statements 

22-43

Safety Statements 

22-24/25-36/37

RIDADR 

3439

WGK Germany 

3

Hazard Note 

Harmful/Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

2926907090

MSDS

• Language:English Provider:4-Amino-2-chlorobenzonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Amino-2-chlorobenzonitrile Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4-Amino-2-chlorobenzonitrile is commonly used as an organic reagent.

Synthesis

Step 4: 2-chloro-4-nitrobenzonitrile (5 g, 0.027 mol) was mixed with hydrazine monohydrate (110 ml) and heated to reaction initiation. Subsequently, the remaining 2-chloro-4-nitrobenzonitrile (35 g, 0.192 mol) was added in batches. The reaction mixture was refluxed for about 30 min after the nitrogen release stopped completely. Upon completion of the reaction, the mixture was slowly poured into stirred ice water. The precipitate was collected by filtration and purified by recrystallization in water to give 2-chloro-4-aminobenzonitrile (25 g, 78% yield, melting point 117 °C).

References

[1] Patent: US4424371, 1984, A

4-Amino-2-chlorobenzonitrile(20925-27-3)Related Product Information

• 4-Aminobenzoic acid
• 2-Chlorobenzonitrile
• 3,4-Dimethylaniline
• p-Anisidine
• ALTRENOGEST
• Glycine
• 4-Amino-3-nitrobenzonitrile
• 2-Aminobenzaldehyde
• Aniline-2-sulfonic acid
• 2,4-Dimethyl aniline
• Methylene dithiocyanate
• 4-Chloroaniline
• 3-Aminophenol
• Benzonitrile
• 6-Aminocaproic acid
• 2-Aminobenzonitrile
• 4-Nitrobenzonitrile
• Aniline