Imperatorin
Imperatorin Basic information
- Product Name:
- Imperatorin
- Synonyms:
-
- 2-g)(1)benzopyran-7-one,9-((3-methyl-2-butenyl)oxy)-7h-furo(
- 6-hydroxy-7-((3-methyl-2-butenyl)oxy)-5-benzofuranacrylicacidelta-lacto
- 6-hydroxy-7-((3-methyl-2-butenyl)oxy)-5-benzofuranacrylicacidelta-lactone
- 6-hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylicacidomega-lactone
- 8-isopentenyloxypsoralene
- 9-((3-methyl-2-butenyl)oxy)-7h-furo(3,2-g)(1)benzopyran-7-one
- 9-[(3-methyl-2-butenyl)oxy]-7h-furo[3,2-g][1]benzopyran-7-one
- IMPERATORIN
- CAS:
- 482-44-0
- MF:
- C16H14O4
- MW:
- 270.28
- EINECS:
- 207-581-1
- Product Categories:
-
- Inhibitors
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Coumarins
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 482-44-0.mol
Imperatorin Chemical Properties
- Melting point:
- 98-100°C
- Boiling point:
- 333.4°C (rough estimate)
- Density
- 1.1311 (rough estimate)
- refractive index
- 1.4350 (estimate)
- storage temp.
- -20°C
- solubility
- DMSO: ≥5mg/mL
- form
- powder
- color
- off-white to light brown
- λmax
- 301nm(MeOH)(lit.)
- Merck
- 14,4925
- InChIKey
- OLOOJGVNMBJLLR-UHFFFAOYSA-N
- LogP
- 2.983 (est)
- CAS DataBase Reference
- 482-44-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 7H-furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]-(482-44-0)
Safety Information
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- LV1575000
- HS Code
- 29419090
- Hazardous Substances Data
- 482-44-0(Hazardous Substances Data)
MSDS
- Language:English Provider:9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one
Imperatorin Usage And Synthesis
Description
Imperatorin is a kind of furocoumarin and phytochemical that present in citrus fruits. It could be isolated from Urena lobata L. (Malvaceae). It is biosynthesized from Umbelliferae in vivo. It has been found that it has anti-hypertrophic and anti-convulsant effects, and is useful in the HIV-1 research. Previous studies have shown that Imperatorin requires the transcription factor Sp1 to exert its inhibitory effect on the HIV-1. It can further inhibit the expression of cyclin D1 to cause cell cycle arrest at G1 stage. Moreover, it can suppress the HIV-1 replication inside the primary T lymphocytes and transformed cell lines. This inhibitory effect on HIV-1 can also be effectively observed in the HeLa cells. In addition, it has also been shown that it can cause apoptosis of human promyelocytic leukaemia via the cytochrome c/caspase-9 pathway.
References
https://www.scbt.com/scbt/product/imperatorin-482-44-0
https://pubchem.ncbi.nlm.nih.gov/compound/imperatorin#section=Top
https://en.wikipedia.org/wiki/Imperatorin
Chemical Properties
White Solid
Uses
Imperatorin (cas# 482-44-0) is a compound useful in organic synthesis.
Definition
ChEBI: A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
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- Product Name:Imperatorin
CAS:482-44-0
Purity:HPLC≥98% Package:20mg
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CAS:482-44-0
Purity:98% Package:10MG;50MG
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- Product Name:MARMELOSIN (IMPERATORIN)
CAS:482-44-0
Remarks:C11428
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- Product Name:IMperatorin
CAS:482-44-0
Purity:98%
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- CAS:482-44-0
Purity:98% (HPLC) Package:25g;100g;500g;1kg
Imperatorin(482-44-0)Related Product Information
- Ferulic Acid
- XANTHOTOXOL
- Benzofuran
- OXYPEUCEDANIN(RG)(PLEASE CALL)
- Isoimperatorin
- 2-(Allyloxy)phenol
- Psoralen
- 7-Methoxybenzofuran
- 8-Methoxypsoralen
- 1,2-Diethoxybenzene
- 2-METHOXYPHENYL ACETATE
- Ostruthine
- ALLOISOIMPERATORIN
- IMPERATOXIN A
- 1-BENZOFURAN-6-OL
- phellopterin
- 7-HYDROXYBENZOFURAN
- 8-METHOXYCOUMARIN